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Artificial allosteric protein switches with machine-learning-designed receptors
Nature Biotechnology
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Zhong Guo, Oleh Smutok, Gyu Rie Lee, Zhenling Cui, Haocheng Qianzhu, Monika Kish, Cagla Ergun yva, Kejia Wu, Roxane Mutschler, Colin J. Jackson, Maria M. Fiorito, Andrew C. Warden, Oliver B. Smith, Alfredo Quijano-Rubio, Thomas Huber, Jonathan J. Phillips, Gottfried Otting, Evgeny Katz, David Baker, Kirill Alexandrov
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2026 |
10.1038/s41587-026-03081-9
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Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy
Nature Biotechnology
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Shuyu Xu, Tianjiao Zhang, Yang Song, Mengxin Wang, Ruiqi Wu, Mofan Li, Haonan Wang, Xinxin Xie, Qingfeng Chen, Xiaotu Ma, Xiaolong Liang
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2026 |
10.1038/s41587-026-03054-y
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Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR
Nature Biotechnology
💎 10 分
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Xiaolin Wei, Yueyuan Xu, Dongchan Yang, Kyukwang Kim, Lizhi Yi, Wenzhe Luo, Xin Lin, Yu Xiang, Ashley B. Williams, Xiaotao Wang, Sweta Srivas, Christabel Tan, Kan Zhang, Wei Li, Yang Eric Li, Feng Yue, Z. Josh Huang, Inkyung Jung, Yarui Diao
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2026 |
10.1038/s41587-026-03013-7
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A retargeted recombinase for precise insertion of large DNA
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💎 10 分
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Frank Buchholz
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2026 |
10.1038/s41587-026-03198-x
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Neuronal recordings with DNA origami
Nature Methods
💎 10 分
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Nina Vogt
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2026 |
10.1038/s41587-026-
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Ten commitments for a bold biotechnology industry
Nature Biotechnology
💎 10 分
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Jeremy M. Levin
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2026 |
10.1038/s41587-026-03251-9
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Simultaneous single-cell profiling of chromatin, transcriptome and surface markers with OneCell CUT&Tag captures epigenomic reprogramming
Nature Biotechnology
💎 10 分
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Anna Schwager, Eve Moutaux, Adeline Durand, Alexandra Van Keymeulen, Amélie Viaene, Mélanie Miranda, Louisa Hadj Abed, Simon Besson-Girard, Marion Lambault, Délia Dupré, Grégoire Jouault, Melissa Saichi, Juliette Bertorello, Simon Dumas, Mathias Schwartz, Marthe Laisné, Justine Marsolier, Manuel Guthmann, Lorraine Bonneville, Urvashi Chitnavis, Déborah Bourc’his, Elisabetta Marangoni, Nicolas Servant, Cédric Blanpain, Leïla Perié, Céline Vallot
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2026 |
10.1038/s41587-026-03259-1
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Biotech's digital twin dilemma
Nature Biotechnology
💎 10 分
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Carrie Arnold
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2026 |
10.1038/s41587-026-03211-3
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Structural motif search across the protein universe with Folddisco
Nature Biotechnology
💎 10 分
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Hyunbin Kim, Rachel Seongeun Kim, Milot Mirdita, Jaewon Yoon, Martin Steinegger
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2026 |
10.1038/s41587-026-03162-9
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Generalist biological artificial intelligence in modeling the language of life
Nature Biotechnology
💎 10 分
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Vishwanatha M. Rao, Serena Zhang, Brian S. Plosky, Patrick D. Hsu, Bo Wang, James Zou, Marinka Zitnik, Eric J. Topol, Pranav Rajpurkar
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2026 |
10.1038/s41587-026-03064-w
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