公开文献目录 · 778
已审核文献 81445 · 778 / 815
Impaired Angiogenesis After Hindlimb Ischemia in Type 2 Diabetes Mellitus: Differential Regulation of Vascular Endothelial Growth Factor Receptor 1 and Soluble Vascular Endothelial Growth Factor Receptor 1
Circulation Research · 2007
DOI: 10.1161/circresaha.107.160630NAFLD and thyroid function: pathophysiological and therapeutic considerations
Trends in Endocrinology & Metabolism · 2022
DOI: 10.1016/j.tem.2022.08.001Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet · 2019
DOI: 10.1016/s0140-6736(19)32517-6MGL-3196, a selective thyroid hormone receptor-beta agonist significantly decreases hepatic fat in NASH patients at 12 weeks, the primary endpoint in a 36 week serial liver biopsy study
Journal of Hepatology · 2018
DOI: 10.1016/s0168-8278(18)30292-7Reduction of Mammary and Liver Lipogenesis and Alteration of Milk Composition during Lactation in Rats by Hypothyroidism
Thyroid · 2007
DOI: 10.1089/thy.2005.0267Myocyte Specific Overexpression of Myoglobin Impairs Angiogenesis After Hind-Limb Ischemia
Arteriosclerosis, Thrombosis, and Vascular Biology · 2008
DOI: 10.1161/atvbaha.108.170951Excess Iodine and High-Fat Diet Combination Modulates Lipid Profile, Thyroid Hormone, and Hepatic LDLr Expression Values in Mice
Biological Trace Element Research · 2012
DOI: 10.1007/s12011-011-9300-xAssociation of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis
Digestive and Liver Disease · 2018
DOI: 10.1016/j.dld.2018.08.012The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice
Laboratory Investigation · 2017
DOI: 10.1038/labinvest.2016.113High-Normal Thyroid Function Predicts Incident Nonalcoholic Fatty Liver Disease Among Middle-Aged and Older Euthyroid Subjects
The Journals of Gerontology: Series A · 2022
DOI: 10.1093/gerona/glab037Comparison of the Influence on the Liver Function Between Thyroid Hormone Withdrawal and rh-TSH Before High-Dose Radioiodine Therapy in Patients with Well-Differentiated Thyroid Cancer
Nuclear Medicine and Molecular Imaging · 2012
DOI: 10.1007/s13139-012-0132-1Requirement for Thyroid Hormone Receptor β in T3Regulation of Cholesterol Metabolism in Mice
Molecular Endocrinology · 2002
DOI: 10.1210/me.2002-0009Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism
European Heart Journal · 2015
DOI: 10.1093/eurheartj/ehu411Phase I study of multi-gene cell therapy in patients with peripheral artery disease
Vascular Medicine · 2016
DOI: 10.1177/1358863x15612148Neovascular potential of adipose-derived stromal cells (ASCs) from diabetic patients
Wound Repair and Regeneration · 2012
DOI: 10.1111/j.1524-475x.2012.00765.xThyroid Hormone Receptor -Deficient Mice Show Complete Loss of the Normal Cholesterol 7 -Hydroxylase (CYP7A) Response to Thyroid Hormone but Display Enhanced Resistance to Dietary Cholesterol
Molecular Endocrinology · 2000
DOI: 10.1210/me.14.11.1739Heme Oxygenase-1 Is Required for Angiogenic Function of Bone Marrow-Derived Progenitor Cells: Role in Therapeutic Revascularization
Antioxidants & Redox Signaling · 2014
DOI: 10.1089/ars.2013.5426Growth factors for angiogenesis in peripheral arterial disease
Cochrane Database of Systematic Reviews · 2017
DOI: 10.1002/14651858.cd011741.pub2Differential action of thyroid hormones and chemically related compounds on the activity of UDP-glucuronosyltransferases and cytochrome P-450 isozymes in rat liver
Biochimica et Biophysica Acta (BBA) - General Subjects · 1990
DOI: 10.1016/0304-4165(90)90167-uAn appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications
Growth Factors · 2022
DOI: 10.1080/08977194.2022.2074843Growth hormone replacement may influence the biological action of thyroid hormone on liver and bone tissue
Growth Hormone & IGF Research · 2021
DOI: 10.1016/j.ghir.2021.101393Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia
Contrast Media & Molecular Imaging · 2019
DOI: 10.1155/2019/2538909Diabetes-associated macrovascular complications: cell-based therapy a new tool?
Endocrine · 2013
DOI: 10.1007/s12020-013-9936-83,5-diiodo-L-thyronine increases de novo lipogenesis in liver from hypothyroid rats by SREBP-1 and ChREBP-mediated transcriptional mechanisms
IUBMB Life · 2019
DOI: 10.1002/iub.2014Thyroid stimulating hormone exhibits the impact on LDLR/LDL-c via up-regulating hepatic PCSK9 expression
Metabolism · 2017
DOI: 10.1016/j.metabol.2017.07.006Oxidized Pork Induces Hepatic Steatosis by Impairing Thyroid Hormone Function in Mice
Molecular Nutrition & Food Research · 2022
DOI: 10.1002/mnfr.202100602Inositol and Hepatic Lipidosis. II. Effect of Inositol Supplementation and Time from Parturition on Serum Insulin, Thyroxine and Triiodothyronine and Their Relationship to Serum and Liver Lipids in Dairy Cows
Journal of Animal Science · 1986
DOI: 10.2527/jas1986.6261693xThe Intrinsic Activity of Thyroxine Is Critical for Survival and Growth and Regulates Gene Expression in Neonatal Liver
Thyroid® · 2021
DOI: 10.1089/thy.2020.0508Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression
American Journal of Physiology-Heart and Circulatory Physiology · 2008
DOI: 10.1152/ajpheart.00149.2008Hyperbaric Oxygen and Bone Marrow–Derived Endothelial Progenitor Cells in Diabetic Wound Healing
Vascular · 2006
DOI: 10.2310/6670.2006.00057Angiogenic properties of human placenta-derived adherent cells and efficacy in hindlimb ischemia
Journal of Vascular Surgery · 2016
DOI: 10.1016/j.jvs.2015.04.387Decreased activity of lecithin:cholesterol acyltransferase and hepatic lipase in chronic hypothyroid rats: Implications for reverse cholesterol transport
Molecular and Cellular Biochemistry · 2003
DOI: 10.1023/a:1023451811547Gene therapy for peripheral arterial disease
Cochrane Database of Systematic Reviews · 2018
DOI: 10.1002/14651858.cd012058.pub2Myometrial mechanotransduction and the timing of parturition: ion-channel pathways linking uterine stretch, calcium signaling, and inflammation
Frontiers in Physiology · 2026
DOI: 10.3389/fphys.2026.1901359Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis
Alcoholism: Clinical and Experimental Research · 2019
DOI: 10.1111/acer.14027Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity
Proceedings of the National Academy of Sciences · 2015
DOI: 10.1073/pnas.1508943112The effect of hypothyroidism and thyroxine replacement on hepatic and intestinal HMG-CoA reductase and ACAT activities and biliary lipids in the rat
Metabolism · 1986
DOI: 10.1016/0026-0495(86)90019-3Influence of the thyroid on the synthesis of cholesterol by liver and skin in vitro
The Journal of Physiology · 1958
DOI: 10.1113/jphysiol.1958.sp006107The role of PYY in improving insulin resistance
Frontiers in Endocrinology · 2026
DOI: 10.3389/fendo.2026.1784709Endothelial deletion of mTORC1 protects against hindlimb ischemia in diabetic mice via activation of autophagy, attenuation of oxidative stress and alleviation of inflammation
Free Radical Biology and Medicine · 2017
DOI: 10.1016/j.freeradbiomed.2017.05.001Reduced Sirtuin1 signalling exacerbates diabetic mice hindlimb ischaemia injury and inhibits the protective effect of a liver X receptor agonist
Journal of Cellular and Molecular Medicine · 2020
DOI: 10.1111/jcmm.15201Is Diabetic Skeletal Fragility Associated with Microvascular Complications in Bone?
Current Osteoporosis Reports · 2017
DOI: 10.1007/s11914-017-0341-8Concise Review: Perspectives and Clinical Implications of Bone Marrow and Circulating Stem Cell Defects in Diabetes
Stem Cells · 2017
DOI: 10.1002/stem.2445Subclinical Hypothyroidism and Hyperthyroidism Have Opposite Effects on Hepatic Very-Low-Density Lipoprotein-Triglyceride Kinetics
The Journal of Clinical Endocrinology & Metabolism · 2012
DOI: 10.1210/jc.2011-2777Autologous stem cell therapy for peripheral arterial disease
Atherosclerosis · 2010
DOI: 10.1016/j.atherosclerosis.2009.08.033Number and Function of Endothelial Progenitor Cells as a Marker of Severity for Diabetic Vasculopathy
Arteriosclerosis, Thrombosis, and Vascular Biology · 2006
DOI: 10.1161/01.atv.0000237750.44469.88Epigenetic regulation of thyroid hormone action in human metabolic dysfunction-associated steatohepatitis
European Thyroid Journal · 2024
DOI: 10.1530/etj-24-0080Exploring the causal relationship between Hashimoto thyroiditis and metabolic-associated fatty liver disease: A Mendelian randomization study
Medicine · 2025
DOI: 10.1097/md.0000000000042533Thyroid Hormones alter Arrhenius Kinetics of Succinate-2,6-dichloroindophenol Reductase, and the Lipid Composition and Membrane Fluidity of Rat Liver Mitochondria
European Journal of Biochemistry · 1995
DOI: 10.1111/j.1432-1033.1995.0576h.xImpaired Regeneration Contributes to Poor Outcomes in Diabetic Peripheral Artery Disease
Arteriosclerosis, Thrombosis, and Vascular Biology · 2020
DOI: 10.1161/atvbaha.119.312863Non-alcoholic fatty liver disease and thyroid dysfunction: A systematic review
World Journal of Gastroenterology · 2014
DOI: 10.3748/wjg.v20.i25.8102Discovery of the Insecticide Chlorantraniliprole as a Thyroid Hormone Receptor β Antagonist Reinforcing Thyroid-Liver Metabolic Disruption to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease
Environmental Science & Technology · 2025
DOI: 10.1021/acs.est.5c07061Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index
Proceedings of the National Academy of Sciences · 2007
DOI: 10.1073/pnas.0702759104Thyroid Hormone-Mediated Selective Autophagy and Its Implications in Countering Metabolic Dysfunction-Associated Steatotic Liver Disease
Endocrinology and Metabolism · 2024
DOI: 10.3803/enm.2024.2068Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression
Translational Research · 2024
DOI: 10.1016/j.trsl.2024.03.011Endothelium dysfunction in hind limb arteries of male Zucker Diabetic-Sprague Dawley rats
Biochemical Pharmacology · 2022
DOI: 10.1016/j.bcp.2022.115319Thyroid Hormone Action on Liver, Heart, and Energy Expenditure in Thyroid Hormone Receptor b-Deficient Mice
Endocrinology · 1998
DOI: 10.1210/endo.139.12.6494Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia
Antioxidants · 2017
DOI: 10.3390/antiox6030047Role of simvastatin and/or antioxidant vitamins in therapeutic angiogenesis in experimental diabetic hindlimb ischemia: effects on capillary density, angiogenesis markers, and oxidative stress
European Journal of Pharmacology · 2012
DOI: 10.1016/j.ejphar.2012.06.002Efficacy and safety of resmetirom in MASLD and MASH: network meta-analysis of randomized clinical trials
Journal of Basic and Clinical Physiology and Pharmacology · 2025
DOI: 10.1515/jbcpp-2024-0140Efficacy and safety of resmetirom for the treatment of nonalcoholic steatohepatitis: a GRADE assessed systematic review and meta-analysis
European Journal of Gastroenterology & Hepatology · 2025
DOI: 10.1097/meg.0000000000002892Efficacy and safety of resmetirom among patients with non-alcoholic steatohepatitis: a systematic review and meta-analysis
Annals of Medicine & Surgery · 2024
DOI: 10.1097/ms9.0000000000002314Comparative Efficacy and Safety of Resmetirom and Efruxifermin for Metabolic Dysfunction-Associated Steatohepatitis: A Network Meta-Analysis of Randomized Controlled Trials
Endocrinology, Diabetes & Metabolism · 2026
DOI: 10.1002/edm2.70218Efficacy and safety of Resmetirom, a selective thyroid hormone receptor-β agonist, in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD): a systematic review and meta-analysis
Scientific Reports · 2024
DOI: 10.1038/s41598-024-70242-8Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis
Endocrine Connections · 2018
DOI: 10.1530/ec-18-0499Dual Effect of Angiotensin-Converting Enzyme Inhibition on Angiogenesis in Type 1 Diabetic Mice
Arteriosclerosis, Thrombosis, and Vascular Biology · 2005
DOI: 10.1161/01.atv.0000149377.90852.d8Retrospective study of the influence of hypothyroidism on liver function before radioiodine therapy in China: a comparison analysis based on patients with differentiated thyroid cancer
BMJ Open · 2022
DOI: 10.1136/bmjopen-2020-045562Insulin modulates ischemia-induced endothelial progenitor cell mobilization and neovascularization in diabetic mice
Microvascular Research · 2011
DOI: 10.1016/j.mvr.2011.09.006Downregulated calmodulin expression contributes to endothelial cell impairment in diabetes
Acta Pharmacologica Sinica · 2023
DOI: 10.1038/s41401-023-01127-1Thyroid function is associated with non-alcoholic fatty liver disease in chronic hepatitis B-infected subjects
Journal of Gastroenterology and Hepatology · 2015
DOI: 10.1111/jgh.12998Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD
Cardiovascular Research · 2014
DOI: 10.1093/cvr/cvt342Hepatic thyroid hormone receptor-β signalling: Mechanisms and recent advancements in the treatment of metabolic dysfunction-associated steatohepatitis
Diabetes, Obesity and Metabolism · 2025
DOI: 10.1111/dom.16117Angiogenic Growth Factors in the Treatment of Peripheral Arterial Disease
Current Vascular Pharmacology · 2007
DOI: 10.2174/157016107781024136Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide–Dependent Mechanisms
Journal of the American Heart Association · 2015
DOI: 10.1161/jaha.115.002527Hypercholesterolemia and tissue-specific differential mRNA expression of type-1 5'-iodothyronine deiodinase under different selenium status in rats
Biological Research · 2006
DOI: 10.4067/s0716-97602006000200013A Possible Explanation of Myxedema and Hypercholesterolemia in Hypothyroidism: Control of Lysosomal Hyaluronidase and Cholesterol Esterase by Thyroid Hormones
Enzyme · 2017
DOI: 10.1159/000459140Thyroid Hormone Receptor-β Agonists in NAFLD Therapy: Possibilities and Challenges
The Journal of Clinical Endocrinology & Metabolism · 2023
DOI: 10.1210/clinem/dgad072Limb Rescue: A New Autologous-Peripheral Blood Mononuclear Cells Technology in Critical Limb Ischemia and Chronic Ulcers
Tissue Engineering Part C: Methods · 2015
DOI: 10.1089/ten.tec.2014.0245Design, synthesis, and biological evaluation of liver-targeting phosphoric acid thyroid hormone receptor agonists for the treatment of metabolic dysfunction-associated steatohepatitis
Bioorganic Chemistry · 2025
DOI: 10.1016/j.bioorg.2025.108880Time Course of Hepatic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity and Messenger Ribonucleic Acid, Biliary Lipid Secretion, and Hepatic Cholesterol Content in Methimazole-Treated Hypothyroid and Hypophysectomized Rats After Triiodothyronine Administration: Possible Linkage of Cholesterol Synthesis to Biliary Secretion*
Endocrinology · 1989
DOI: 10.1210/endo-125-1-459Database mining of ZINC15 natural compounds reveals potential thyroid receptor β agonists for NAFLD management: an in silico study
Digital Discovery · 2025
DOI: 10.1039/d5dd00146cEffects of the synthetic liver X receptor agonist T0901317 on the growth hormone and thyroid hormone axes in male rats
Endocrine · 2008
DOI: 10.1007/s12020-008-9067-9Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes
Advanced Healthcare Materials · 2016
DOI: 10.1002/adhm.201500993Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs
Redox Biology · 2022
DOI: 10.1016/j.redox.2022.102449Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia
Circulation Research · 2017
DOI: 10.1161/circresaha.117.310619Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines
Arteriosclerosis, Thrombosis, and Vascular Biology · 2015
DOI: 10.1161/atvbaha.114.305048Importance of insulin resistance to vascular repair and regeneration
Free Radical Biology and Medicine · 2013
DOI: 10.1016/j.freeradbiomed.2013.02.028Medical management of peripheral arterial disease
Journal of Thrombosis and Haemostasis · 2005
DOI: 10.1111/j.1538-7836.2005.01368.xThyroid hormone analogues and derivatives: Actions in fatty liver
World Journal of Hepatology · 2014
DOI: 10.4254/wjh.v6.i3.114Inhibition of Aldehyde Dehydrogenase-Activity Expands Multipotent Myeloid Progenitor Cells with Vascular Regenerative Function
Stem Cells · 2018
DOI: 10.1002/stem.2790Endothelial deletion of PKCδ prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischemic limb
Diabetes and Vascular Disease Research · 2021
DOI: 10.1177/1479164121999033A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG-055009, a novel thyroid hormone receptor beta (THR-β) agonist for metabolic dysfunction-associated steatohepatitis (MASH), in healthy participants
Clinical Pharmacology in Drug Development · 2026
DOI: 10.1002/cpdd.1606Comparative efficacy of THR-β agonists, FGF-21 analogues, GLP-1R agonists, GLP-1-based polyagonists, and Pan-PPAR agonists for MASLD: A systematic review and network meta-analysis
Metabolism · 2024
DOI: 10.1016/j.metabol.2024.156043The Thyroid Hormone Receptor-β Agonist GC-1 Induces Cell Proliferation in Rat Liver and Pancreas
Endocrinology · 2006
DOI: 10.1210/en.2005-1561Upper extremity ischemia treated with tissue repair cells from adult bone marrow
Journal of Vascular Surgery · 2010
DOI: 10.1016/j.jvs.2010.04.020GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease
Gene Expression · 2017
DOI: 10.3727/105221617x14968563796227Therapeutic Angiogenesis in Peripheral Arterial Disease: Can Biotechnology Produce an Effective Collateral Circulation?
European Journal of Vascular and Endovascular Surgery · 2004
DOI: 10.1016/j.ejvs.2004.03.021Reduced Expression of Vascular Endothelial Growth Factor Paralleled With the Increased Angiostatin Expression Resulting From the Upregulated Activities of Matrix Metalloproteinase-2 and -9 in Human Type 2 Diabetic Arterial Vasculature
Circulation Research · 2006
DOI: 10.1161/01.res.0000232352.90786.faN-3 polyunsaturated fatty acids alleviate high glucose-mediated dysfunction of endothelial progenitor cells and prevent ischemic injuries both in vitro and in vivo
The Journal of Nutritional Biochemistry · 2017
DOI: 10.1016/j.jnutbio.2017.01.009Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway
Journal of Endocrinology · 2010
DOI: 10.1677/joe-09-0448